At a glance
- CAS number
- 25513-46-6
- INCI name
- Polyglutamic Acid
- Function
- humectant, film former, skin conditioning
- Typical use level
- 0.5%–5%
- Solubility
- water
- Stable pH
- 4–7
CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.
Also known as
PGA gamma-PGA poly-gamma-glutamic acid natto gum fermented glutamic acid polymer
Compatibility
Works well with:
Hyaluronic Acid Niacinamide Glycerin Panthenol Ceramides Sodium PCA
Polyglutamic Acid is broadly compatible with most water-phase actives and humectants, and is often layered with hyaluronic acid for complementary moisture-retention effects. It performs best in slightly acidic to neutral formulas; highly alkaline conditions can hydrolyze the peptide backbone. No widely documented incompatibilities, though high electrolyte concentrations may reduce its hygroscopic performance.
Formulation notes
Polyglutamic Acid is a naturally derived biopolymer produced via bacterial fermentation of Bacillus subtilis, best known from natto. It functions as a potent humectant — reported to hold significantly more moisture than hyaluronic acid — while also forming a lightweight occlusive film on the skin surface that reduces transepidermal water loss. It is well tolerated at typical use levels, though formulators should confirm molecular weight grade, as high-MW and low-MW forms differ in skin penetration depth and sensory profile.
Related ingredients
- Sodium HyaluronateHumectant
- Hydrogenated PolyisobuteneEmollient
- Butylene GlycolHumectant
- Pentylene GlycolHumectant
- Propylene GlycolHumectant
- UreaHumectant