At a glance
- CAS number
- 104-29-0
- INCI name
- Chlorphenesin
- Function
- preservative, antimicrobial
- Typical use level
- 0.1%–0.3%
- Solubility
- both
- Stable pH
- 3–8
CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.
Also known as
chlorphenesin 3-(4-Chlorophenoxy)-1,2-propanediol 3-(4-chlorophenoxy)propane-1,2-diol Chlorphenesinum Chlorphenesine Clorfenesina 1,2-Propanediol, 3-(4-chlorophenoxy)- 3-(p-Chlorophenoxy)-1,2-propanediol Glycerol alpha-p-chlorophenyl ether p-Chlorophenyl-alpha-glyceryl ether 3-(p-Chlorophenoxy)propane-1,2-diol RefChem:57031
Compatibility
Works well with:
Phenoxyethanol Ethylhexylglycerin Caprylyl Glycol Glycerin Propylene Glycol Niacinamide Hyaluronic Acid Carbomer Xanthan Gum
Use caution with:
High-concentration Cationic Surfactants Nonionic Surfactants (high HLB, high concentration)
Chlorphenesin is commonly paired with phenoxyethanol or caprylyl glycol for broad-spectrum preservation with potential reduction in individual use levels. High concentrations of nonionic or cationic surfactants can reduce its antimicrobial efficacy through micellar entrapment. It is generally stable across a wide pH range, making it versatile in many formulation types.
Formulation notes
EU Cosmetics Regulation limits use to a maximum of 0.3% in rinse-off and leave-on products. Primarily effective against gram-negative bacteria and fungi; often combined with other preservatives for full-spectrum coverage. Not approved for use in products intended for children under 3 in some jurisdictions — check local regulations.
Related ingredients
- Potassium SorbatePreservative
- Salicylic AcidActive
- Benzyl AlcoholPreservative
- Sodium BenzoatePreservative
- Azelaic AcidActive
- Kojic AcidActive