At a glance
- CAS number
- 58-08-2
- INCI name
- Caffeine
- Function
- active, antioxidant, skin conditioning
- Typical use level
- 0.5%–3%
- Solubility
- water
- Stable pH
- 4–7
CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.
Also known as
caffeine Guaranine 1,3,7-Trimethylxanthine Methyltheobromine Theine Thein Cafeina Caffein Cafipel Koffein Mateina Alert-pep
Compatibility
Works well with:
Niacinamide Hyaluronic Acid Glycerin Panthenol Allantoin Green Tea Extract Retinol Peptides Vitamin E
Use caution with:
Tannic Acid High-concentration Tannins Strong Oxidizing Agents
Caffeine can form insoluble complexes with tannins and polyphenols at higher concentrations, potentially causing precipitation or reduced efficacy. It is generally stable and compatible with most common cosmetic actives across a moderate pH range. Strong oxidizing agents may degrade the xanthine structure over time.
Formulation notes
No specific regulatory maximum in EU cosmetics; typical use is 0.5–3% in eye creams, serums, and slimming products. Solubility in water is approximately 20 mg/mL at room temperature (2%), so formulations above this level may require warming or a co-solvent. No known sensitization concerns at typical use levels.
Related ingredients
- Azelaic AcidActive
- BakuchiolActive
- BisabololActive
- Centella Asiatica ExtractActive
- Kojic AcidActive
- ResveratrolActive