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Humectant

Betaine

Betaine is a humectant, osmoprotectant, skin-conditioning agent, hair conditioning used in cosmetic and personal-care formulation. Typical use level is 0.5%–5%. It is water-soluble. Stable in the pH 3–9 range.

At a glance

CAS number
107-43-7
INCI name
Betaine
Function
humectant, osmoprotectant, skin-conditioning agent, hair conditioning
Typical use level
0.5%–5%
Solubility
water
Stable pH
3–9

CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.

Also known as

Trimethylglycine TMG Glycine Betaine Lycine Natural Betaine

Compatibility

Works well with:
Glycerin Hyaluronic Acid Niacinamide Panthenol Allantoin Lactic Acid

Betaine is broadly compatible with most cosmetic ingredients across a wide pH range, making it a highly versatile humectant. It works synergistically with other humectants such as glycerin and hyaluronic acid to enhance moisture retention. No significant incompatibilities are commonly reported at typical use levels.

Formulation notes

Betaine is a naturally derived zwitterionic compound (commonly sourced from sugar beet molasses) that functions primarily as a humectant and osmoprotectant, helping skin cells maintain hydration under osmotic stress. It also provides a smooth, silky skin feel and can help reduce the irritation potential of surfactants in cleansing formulations. Betaine is generally considered safe and well-tolerated, even for sensitive skin types.

Frequently asked questions

What is Betaine?

Betaine is a humectant, osmoprotectant, skin-conditioning agent, hair conditioning used in cosmetic and personal-care formulation. Typical use level is 0.5%–5%. It is water-soluble. Stable in the pH 3–9 range.

What is Betaine used for?

Betaine is used as humectant, osmoprotectant, skin-conditioning agent, hair conditioning in cosmetic and personal-care formulations.

What is the typical use level of Betaine?

Betaine is typically used at 0.5%–5% in the finished formulation. Always confirm against your supplier's technical data sheet.

What is the CAS number of Betaine?

The CAS registry number for Betaine is 107-43-7. Its INCI name is Betaine.

At what pH is Betaine stable?

Betaine is generally stable in the pH 3–9 range.

What ingredients are compatible with Betaine?

Betaine works well with Glycerin, Hyaluronic Acid, Niacinamide, Panthenol, Allantoin, Lactic Acid.

Related ingredients

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