Hemisqualane

At a glance

CAS number

3891-98-3

INCI name

Hemisqualane

Function

emollient, solvent, skin-conditioning agent

Typical use level

1%–25%

Solubility

oil

CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.

Also known as

2,6,10-trimethyldodecane C15 isoparaffin half-squalane plant-derived hemisqualane

Compatibility

Works well with:
Squalane Jojoba Esters Dimethicone Caprylic/Capric Triglyceride Tocopherol Cyclomethicone

Hemisqualane is a highly stable, non-polar isoparaffin that is compatible with most oil-phase ingredients including silicones, natural esters, and plant oils. It does not saponify and is inert to most cosmetic actives. No notable incompatibilities are established under typical formulation conditions.

Formulation notes

Hemisqualane is a lightweight, branched-chain C15 hydrocarbon (half the molecular weight of squalane) that delivers a dry, fast-absorbing, non-greasy skin feel, making it popular in serums, primers, and lightweight moisturizers. It functions as an emollient and carrier solvent for oil-soluble actives and is often used to reduce the heaviness of richer emollient blends. It is considered biodegradable and can be derived from sugarcane-based farnesene, making it appealing for sustainable and clean-beauty formulations.

Frequently asked questions

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