At a glance
- CAS number
- 100403-19-8
- INCI name
- Ceramide NP
- Function
- barrier repair, emollient, skin-identical ingredient, moisturizer
- Typical use level
- 0.01%–2%
- Solubility
- oil
- Stable pH
- 4–7
CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.
Also known as
Ceramide 3 N-stearoylphytosphingosine Ceramide III Phytoceramide
Compatibility
Works well with:
Cholesterol Fatty Acids Ceramide AP Ceramide EOP Niacinamide Hyaluronic Acid
Ceramide NP works synergistically with cholesterol and free fatty acids to mimic the natural skin lipid matrix, typically in a molar ratio of 1:1:1 or 3:1:1 ceramide:cholesterol:fatty acid. It is best delivered via a lamellar emulsion system or liposomal encapsulation to maximize skin penetration and efficacy. Avoid high-temperature processing above 70°C for extended periods to prevent degradation.
Formulation notes
Ceramide NP is a skin-identical ceramide naturally found in the stratum corneum, where it plays a critical role in maintaining the skin barrier and reducing transepidermal water loss. Formulators use it to restore lipid barrier integrity in dry, compromised, or sensitive skin, making it a key active in moisturizers, barrier creams, and eczema-targeted products. Because it is lipophilic and waxy, it typically requires solubilization in a carrier oil or emulsifier system before incorporation.
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