Do blue light protection serum claims require FDA drug approval?

No. In the United States and EU, blue light or HEV protection claims are treated as cosmetic claims, not drug claims, as long as they describe an antioxidant or barrier benefit rather than preventing a disease. Your manufacturer should provide a claims-support dossier or refer you to an in-vitro testing lab. AJ Cosmo Labs connects you with formulators experienced in crafting defensible cosmetic claims.