Salicylic acid (0.5–2%) is the gold standard keratolytic. Niacinamide (2–10%) regulates sebum without triggering drug-pathway compliance. CICA and centella asiatica soothe post-blemish irritation. Microneedle patches can deliver retinol or hyaluronic acid transdermally but require substantially more R&D investment. Your cosmetic chemist should balance efficacy, stability, and regulatory fit for each active.
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